Prognostic value of adiponectin in coronary artery disease: Role of diabetes and left ventricular systolic dysfunction.

Abstract Objectives Adiponectin (AD) promotes insulin sensitivity and has anti-atherogenic properties. However, the role of AD on clinical outcomes in coronary artery disease (CAD) is controversial. We analyzed whether AD was an independent predictor of all-cause mortality and hospitalization in patients with CAD. Method We prospectively enrolled 138 patients with stable CAD, with or without type 2 diabetes and with or without left ventricular dysfunction. A telephone follow-up was conducted to register long term outcomes. Sensitivity/specificity ratio for AD was investigated with ROC analysis and the independent role of AD on outcome was evaluated with Cox regression model of analysis. The survival rate was represented by Kaplan Meyer curves. Results Of 138 patients, 61 had type 2 diabetes and 71 left ventricular systolic dysfunction (EF p 13.2ng/ml had a significantly higher risk of death (HR=6.50; 95% CI: 2.40–17.70), but not of cardiovascular hospitalization (HR=0.87; 95% CI: 0.31–2.44). AD predictivity remained significant also in patients with type 2 diabetes and with left ventricular systolic dysfunction. Conclusion In stable CAD, an AD value of >13.2ng/ml independently predicts a 6-fold increased risk of all-cause mortality.