305 CF registry in Northern Greece over a 7 year period

Aim To evaluate the epidemiologic data of CF in Northern Greece over a seven year period. Method Demographic, genetic and clinical symptoms were collected in a database, according to the European CF Registry. Data collection was completed in a seven year period (2008–2014). All the information was obtained from patients' clinical records. We have no neonatal screening in Greece so far. Results Totally 122 CF patients were identified in 2008, compared to 145 in 2014. Mean age increased from 14.4±8 years in 2008, to 17.1±11 years in 2014. The proportion of adults increased: 31% of patients were older than 18 years in 2008, while 46.3% were adults in 2014. Mean age of diagnosis was 1.16±0.53 years. Eighty percent of patients were identified with the DF508 mutation (23.75% were homozygous). Thirty percent of our patients were chronically colonized with Pseudomonas aeruginosa ; Burkholderia cepacia was not isolated in any of our patients. 94% had pancreatic insufficiency and 30% were malnourished (BMI 2 ), 3.66% had meconium ileus and 7.3% had CFRD. The FEV 1 among patients aged 6–18 years, was 81±29% in 2008 and 87.75±32% in 2014. One of our patients had undergone lung transplantation. Conclusions Mean age and FEV1 have increased over the last 7 years, in our CF center. This may be due to the introduction of more aggressive treatment over the last years.