New facile one-pot synthesis of S-alkyl thiolcarbamates from xanthogenate in water

A simple and efficient one-pot synthesis was developed for the preparation of S-alkyl thiolcarbamates from xanthogenate without catalyst using water as a sol- vent. The water can be recycled after removal of the product. The significant features of this protocol are: operational simplicity, mild reaction conditions, recycling of solvent and high product yields. Starting basic alkyl xanthogenate reacts with alkyl ammonium sulfate (aryl ammonium sulfate) and hydrogen peroxide (molar ratio 1:0.55:1) in water at 40 C for 1 h, followed by additional heating at 70-110 C for 1-2.3 h. Good to excellent yields were achieved using ammonium sulfate in 10 % molar excess.