Deneysel subaraknoid kanamada karotid cismin nöron korumasındaki rolü

Objective: Carotid bodies are known as main arterial chemoregulatory units. Despite well known that carotid bodies have an important role in cerebral circulation and blood pH regulation, their roles has not been investigated in subarachnoid haemorrhage. We investigated whether there is neuroprotective effect of neuron density of carotid bodies on the brain in subarachnoid haemorrhage. Methods: Twenty hybrid rabbits were studied. Four of them were used as reference group (n=4) and the remaining was obliged to subarachnoid haemorrhage by injecting autologous blood into their cisterna magna (n=16) and sacrificed after one month. All carotid bodies and brains examined histopathologically using by stereologic methods. The relationship between the neuronal density of carotid body and degenerated neuron density of the hippocampus were compared statistically. Results: Five rabbits with subarachnoid haemorrhage dead during the follow-up time (n=5). The average neuronal density of carotid body was 4500p500 cells/mm3 and of hippocampus 170.000p17.000 cell/mm3 in normal rabbit family. The degenerated neuron density of the hippocampus was 20.000p3.000 cells/mm3 in rabbits with have high neuron density of carotid body and was 65.000p8.000 cells/mm3 in rabbits with low neuron density of carotid body. The differences between the neuronal density of carotid body and the degenerated neuron numbers of the hippocampus were significant. Conclusion: The neuron density of carotid body may play an important role on the protection of brain in subarachnoid haemorrhage.