Pregnancy and birth after intracytoplasmic sperm injection with totally immotile sperm recovered from the ejaculate

Abstract Objective: To report the birth of two healthy children after intracytoplasmic sperm injection (ICSI) with totally immotile spermatozoa recovered from the ejaculate. Design: Retrospective case report. Setting: University-based hospital. Patient(s): Four couples in whom spermatozoa recovered from the ejaculate were totally immotile but presented normal vitality scores. Intervention(s): Therapeutical IVF-ET attempts coupled with ICSI. Main Outcome Measure(s): Fertilization and pregnancy results after ICSI. Results: With random sperm injection, 19 of the 36 injected oocytes showed normal fertilization and cleavage. One of four patients had a twin pregnancy that resulted in birth of two healthy children. Conclusion(s): In cases in which totally immotile ejaculated sperm present normal vitality scores, normal clinical outcomes can be achieved by using the usual random sperm selection during conventional ICSI.