A significant decreased in the frequency of Clostridioides difficile infection at the Italian Hospital of Desio over the last decade.

Abstract Clostridiodes difficile infection (CDI) is the most important cause of healthcare-associated diarrhea. The decreasing trend of CDI from 15 % to 4 % observed at the Italian Hospital of Desio over a 10-year period is due to prevention strategies. Our data highlight the importance of surveillance studies to control CDI.