HF-LPLI-treated tumor cells induce NO production in macrophage
2013
High fluence low-power laser irradiation (HF-LPLI) provides a new stimulator to trigger cell apoptosis, and it is well
known that apoptotic cells provide antigens to effectively trigger recognition by the immune system. In order to
investigate the effect of HF-LPLI on the professional antigen-presenting cell (APC) function, in our primary study, we
focused our attention on the effect of HF-LPLI-treated tumor cells on macrophages phagocytosis and NO production.
Both confocal microscopy and flowcytometry analysis showed that HF-LPLI (120 J/cm 2 ) induced significantly EMT6
death. Further experiments showed that HF-LPLI-treated EMT6 cells could be phagocyted by the murine macrophage
cells RAW264.7, and could induce NO production in macrophages. Taken together, our results indicate that
HF-LPLI-treated tumor cells effectively regulated the immune system. The HF-LPLI effect on the APC function needs
to be further studied.
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