Neuropatía óptica inflamatoria recurrente crónica (CRION) sin detección de anticuerpos IgG-NMO

Chronic relapsing inflammatory optic neuropathy is a disease that should be distinguished from demyelinating optic neuropathy (ON). Long-term immunosuppressive therapy is usually necessary and either an inflammatory granulomatous origin or a relationship with neuromyelitis optica (NMO) is hypothesized. We report a 43-year-old man who suffered from several ON episodes affecting one eye or the other. These ON attacks completely disappeared with steroid therapy but relapsed after its withdrawal. lgG-NMO antibodies were negative.