Causes and Consequences of Polycystic Ovary Syndrome: Insights from Mendelian Randomization.

Context Though polycystic ovarian syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age, risk factors that may cause the syndrome are poorly understood. Based on epidemiologic studies, PCOS is thought to cause several adverse outcomes such as cardiovascular disease; however, the common presence of co-morbidities such as obesity may be responsible for such associations, rather than PCOS in and of itself. To overcome the limitations of observational studies, investigators have employed Mendelian randomization (MR), which uses genetic variants to interrogate causality between exposures and outcomes. Evidence acquisition To clarify causes and consequences of PCOS, this review will describe MR studies involving PCOS, both as an exposure and as an outcome. The literature was searched using the terms Mendelian randomization, Mendelian randomization, polycystic ovary syndrome, polycystic ovarian syndrome, and PCOS (to May 2021). Evidence synthesis MR studies have suggested that obesity, testosterone levels, fasting insulin, serum SHBG concentrations, menopause timing, male-pattern balding and depression may play a causal role in PCOS. In turn, PCOS may increase the risk of estrogen receptor positive breast cancer, decrease the risk of endometrioid ovarian cancer, and have no direct causal effect on type 2 diabetes, coronary heart disease, or stroke. Conclusions The accumulation of genome-wide association studies in PCOS has enabled multiple MR analyses identifying factors that may cause PCOS or be caused by PCOS. This knowledge will be critical to future development of measures to prevent PCOS in girls at risk as well as prevent complications in those who have PCOS.