Vinpocetine tubular crystal and preparation method thereof

2015 
The invention relates to a vinpocetine tubular crystal and a preparation method thereof. The vinpocetine tubular crystal is prepared by the following steps: adding vinpocetine to a solvent, starting for stirring at a speed of 100-800rpm, increasing temperature to 40-95 DEG C so as to enable the vinpocetine to be dissolved to obtain a 16-50mg/ml vinpocetine solution; and adding water to the solution, filtering and washing after the temperature is kept constant for 5-60min, and drying for 2-8h in a vacuum drying box at 20-80 DEG C so as to obtain the vinpocetine tubular crystal. The vinpocetine product prepared by the invention is of a crystal structure which has closed or non-closed channels; the yield is 60-85%, bulk density is 0.25-0.4g/ml and the dissolution rate is increased by 20-40%; the tubular crystal, applied to the field of medicine, is capable of improving the problem of low dissolution rate of the vinpocetine in the water, promoting medicine absorption and enhancing the medicine efficiency and the bioavailability. The preparation method, which is capable of preparing the vinpocetine tubular crystal by a simple one-step dissolving process, is simple in production process and easy to implement industrial production.
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