Thiazolylinhibitorer of tyrosine kinases Tec family

A compound of formula I diastereomers, enantiomers or salts thereof, where Q2 is aryl or heteroaryl; Z is (1) -O-, (2) -S-, (3) CR4R5-, (4) CR4R5-O-CR4aR5a-, (5) NR4b-CR4aR5a--CR4R5, or (6) S-CR4R5-, R1, R1ab, R 1a C and R1ad are independently (1) hydrogen or R6, (2) o OH OR6, (3) C (O) qH or is C (O) q R 6, where q is 1 or 2, (4) halo, or (5) Z4NR7Ra, R2 and R3 are each independently H or is Z4-R6a; R6, R6a and R6b are independently alkyl, cycloalkyl, aryl, aralkyl, heterocyclo or heterocycloalkyl, each of which is unsubstituted or substituted with Z1, Z2 and one or more groups Z3; R4, R4a, R4b, R5 and R5a are each independently hydrogen, alkyl, aryl, aralkyl, cycloalkyl, or heteroarylalkyl; R7 and R8 are each independently hydrogen or is Z4R6b; X2 is CZ3a, NZ3a, O or S; Z3a is H, hydroxy, optionally substituted alkyl, optionally substituted heterocyclo, -OZ6, -C (O) qH, -C (O) qZ6a, -Z4-NZ7Z8 o Z4-N (Z10) -Z5-Z6; n is 1 to 3; m is CARTA 2; Z1, Z2 and Z3 are each independently (1) hydrogen or Z6, (2) OH o OZ6, (3) C (O) qH or is C (O) qZ6, (4) halo, (5) Z4-NZ7Z8 ?, (6) Z4-N (Z10) -Z5-Z6, (7) Z4-N (Z10) -Z5-H, or (8) oxo; Z4 and Z5 are independently (1) a single bond, (2) C (O) -, (3) S (O) q-, or (4) alkyl; Z6 and Z6A are independently (i) alkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, aryl, aralkyl or heterocycle, (ii) a group (i) which is itself substituted with one or more of the same or different groups (i), or (iii) a group (i) or (ii) which is independently substituted with one or more of groups (2) to (8) of the definition of Z1; Z7, Z8 and Z10 are each independently hydrogen or is Z4-Z6A.