Attenuation Effect of Tianzhicao Capsules on Doxorubicin Induced Toxicity

OBJECTIVE: To search the attenuation action of Tianzhicao capsules on doxorubicin induced toxicity.METHODS: Hepatoma H22 tumor-bearing mice were administrated with Tianzhicao capsules and doxorubicin orally.Then the growth of mice,changes in electrocardiogram (ECG),myocardial enzymes and myocardial morphological changes were determined after administration.RESULTS:Tianzhicao capsules were not in synchronism with the action potential depolarization in ventricular muscle and cardiac injury induced by doxorubicin.Tianzhicao capsule also inhibited the increase of serum LHD and doxorubicin-induced cardiac injury.CONCLUSION: Tianzhicao capsules show attenuation effect on doxorubicin-induced toxicity.