Toxicity and radiation dosimetry studies of the serotonin transporter radioligand [18 F]AFM in rats and monkeys

Ya-Yao Huang,Chen-Yi Cheng,Wen-Sheng Huang,Kuo-Hsing Ma,Ta-Wei Tseng,Ta-Kai Chou,Yiyun Huang,Chyng-Yann Shiue

Toxicity and radiation dosimetry studies of the serotonin transporter radioligand [18 F]AFM in rats and monkeys

2014

Ya-Yao Huang
Chen-Yi Cheng
Wen-Sheng Huang
Kuo-Hsing Ma
Ta-Wei Tseng
Ta-Kai Chou
Yiyun Huang
Chyng-Yann Shiue

Background [18 F]AFM is a potent and promising PET imaging agent for the serotonin transporter. We carried out an acute toxicity study in rats and radiation dosimetry in monkeys before the translation of the tracer to humans.

Keywords:

Serotonin transporter
Acute toxicity
Dosimetry
Radiation
Toxicity
Atomic force microscopy
Nuclear medicine
Molecular biology
Medicine
Radioligand
pet imaging
Pharmacology
Pathology

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