Effect of perioperative administration of dexketoprofen on the dose of morphine in patient-controlled analgesia after artificial hip jiont replacement

Objective: To evaluate the effectiveness and analgesic efficacy of dexketoprofen administered perioperatively by comparing the dose and adverse effect of morphine in postoperative patient-controlled anesthesia.Methods: Fifty ASA Ⅰ or Ⅱ patients undergoing artificial hip joint replacement were randomly divided into 2 groups: group D,receiving dexketoprofen of 25 mg both 24 hours before and 48 hours after the surgery,and group P,receiving placebo.Combined spinal-epidural anaesthesia was used.Hyperbaric bupivacaine of 0.5% and morphine of 0.6 mg were administered intrathecally.Lidocaine of 2% was used for epidural block,and morhpine was used in postoperative patient-controlled anesthesia.Resutls: After the surgery,patients in group D experienced less degree of pain compared with patients in group P(P0.01).The dose of morphine in group D was much less than that in group P(P0.01).The incidenc of nausea and vomitting 18 hours after the surgery in group D was lower than that in group P(P0.01).The sedative effect 15 hours after surgery in group D was better than that in group P(P0.01).Conclusion: Dexketoprofen administered 1 day before and 2 days after the artificial hip joint replacement may markedly enhance the analgesic effect of morphine and decrease the dose and the incidence of related adverse effect of morphine.