The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess
2000
Arylmalonate decarboxylase (EC. 4. 1. 1. 76) catalysed
decarboxylation followed by enantioface-differentiating protonation of
[α-2H]- and [α-1H]phenylmalonic acid in
1H2O and 2H2O respectively,
gave highly enantiomerically enriched (R)- and
(S)-[α-2H]phenylacetic acid in quantitative
yields.
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