Aged B-cells with proinflammatory and autoreactive characteristics are expanded in a proportion of MS patients

[Claes, N.; Fraussen, J.; Stinissen, P.; Vanwijmeersch, B.; Somers, V.] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium. [Claes, N.; Fraussen, J.; Stinissen, P.; Vanwijmeersch, B.; Somers, V.] Hasselt Univ, Sch Life Sci, Transnatl Univ Limburg, Diepenbeek, Belgium. [Vanwijmeersch, B.] Rehabilitat & MS Ctr, Overpelt, Belgium. [Hupperts, R.] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Neurosci, Maastricht, Netherlands. [Hupperts, R.] Orbis Med Ctr, Dept Neurol, Sittard, Netherlands.