Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43G298S ALS mouse model

Hans-Peter Müller,David A. Brenner,Francesco Roselli,Diana Wiesner,Alireza Abaei,Martin Gorges,Karin M. Danzer,Albert C. Ludolph,William Tsao,Philip C. Wong,Volker Rasche,Jochen H. Weishaupt,Jan Kassubek

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43G298S ALS mouse model

2019

Hans-Peter Müller
David A. Brenner
Francesco Roselli
Diana Wiesner
Alireza Abaei
Martin Gorges
Karin M. Danzer
Albert C. Ludolph
William Tsao
Philip C. Wong
Volker Rasche
Jochen H. Weishaupt
Jan Kassubek

Background In vivo diffusion tensor imaging (DTI) of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis (ALS).

Keywords:

Magnetic resonance imaging
Corticospinal tract
Neurology
Nuclear magnetic resonance
Diffusion MRI
Amyotrophic lateral sclerosis
Medicine
Motor cortex
Fractional anisotropy
Cortex (botany)
Hyperintensity
Pathology

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