δ-Tocotrienol tend to attenuate plasma triglyceride levels (829.12)

Tocotrienols have been shown to reduce the risk factors of cardiovascular disease. α- and γ-tocotrienols are predominant forms of tocotrienols on the market. An animal study was conducted to examine the hypocholesterolemic effects of δ-tocotrienol. 45 male Sprague Dawley rats (6 week old) were randomly assigned into four groups: normal fat control group (NFC) (n=9), high fat control group (HFC) (n=12), pure δ- tocotrienol group (dT3) (n=12), and δ-tocotrienol rich oil group (DGT) (n=12). The NFC received AIN 93 diet (10% of energy from fat) and the other groups received high fat diet (38% of energy from fat) for 3 weeks. The treatment groups were gavaged with 20 mg dT3 and 25.25 mg DGT dispensed in 0.5ml of 5% tween-eighty. The control groups were treated with the same vehicle alone in the same manner. Blood samples were collected by cardiac puncture for cholesterol profile. Plasma triglyceride was 7% and 12% lower in dT3 and DGT groups than HFC group. No significant differences were found in plasma total...