Controlling Bayes directional false discovery rate in random effects model

Starting with a decision theoretic formulation of simultaneous testing of null hypotheses against two-sided alternatives, a procedure controlling the Bayesian directional false discovery rate (BDFDR) is developed through controlling the posterior directional false discovery rate (PDFDR). This is an alternative to Lewis and Thayer [2004. A loss function related to the FDR for random effects multiple comparison. J. Statist. Plann. Inference 125, 49–58.] with a better control of the BDFDR. Moreover, it is optimum in the sense of being the non-randomized part of the procedure maximizing the posterior expectation of the directional per-comparison power rate given the data, while controlling the PDFDR. A corresponding empirical Bayes method is proposed in the context of one-way random effects model. Simulation study shows that the proposed Bayes and empirical Bayes methods perform much better from a Bayesian perspective than the procedures available in the literature. © 2007 Elsevier B.V. All rights reserved.