The risk of arterial hypertension development in Siberian Group of Chemical Enterprises personnel

PURPOSE: to study risk factors of arterial hypertension (AH), their significance for AH pathogenesis in atomic power plants employees occupationally exposed to long-term ionizing radiation in a "low" dose range (cumulative external radiation doses in the range up 1 Sv). The case-control study was carried in the cohort of workers aged 40-50 ever employed at the Siberian Group of Chemical Enterprises (SGCE) between 2003-2005. 970 persons were examined by standardized epidemiological methods. "Case" (n = 359) was found to be a recent AH case (less than 3 years) in SGCE employees whose average length of service is 3 years. "Control" (n = 611) - healthy men of the same age, length of service and working conditions. Risk of AH development (odds ratio (OR) = 1.6 (1.1; 2.37) was found to be higher in radiation workers in comparison with non-radiation ones without any linear dependence of risk upon cumulative external gamma-radiation dose in the range under study (OR in a cumulative external radiation dose range 7.3-21.3 mSv = 1.6 (0.96; 2.51); OR in a cumulative external radiation dose range 21.4-68.5 mSv = 1.7 (1.04; 2.67); OR in a cumulative external radiation dose range 68.6-864 mSv = 1.6 (1.01; 2.57). Not only traditional risk factors such as: obesity (OR = 7.1 (5.06; 10.1), frequent alcohol usage (OR = 1.3 (1.06; 1.63)), dyslipidemia (OR = 2.1 (1.61; 2.08)); hyperhomocisteinemia (OR = 1.4 (1.09; 1.72)); psychoemotional (OR = 1.4(1.11; 1.89)), hereditary aggravation (OR = 2.2 (1.75; 2.9)) in SGCE personnel, but also technogenic explosion descriptions are related to AH development. The long-term occupational external gamma-radiation in a dose range up 1 Sv potentiates a negative influence of CVD traditional risk factors (for hypercholesterinemia OR = 1.9 (1.3; 2.9), for AH OR = 3.1 (2.2; 4.6)) that leads to increase in risk coefficients for 30-60% in persons exposed to traditional and technogenic factors impact (for hypercholesterinemia and ionizing radiation OR = 2.5 (1.7; 3.2); for AH and IR OR = 3.9 (2.8; 5.2)) in comparison with non-radiation personnel.