Progressive Supranuclear Palsy: Electroencephalographic Studies

Thirty-one electroencephalograms from 12 patients with progressive supranuclear palsy (PSP) were examined. Four patients had initially abnormal records. Five other patients had initially normal records, but all developed abnormalities during the follow-up period. Three of 12 patients had normal records; each of them had only one record taken. The results indicate that the course of PSP is usually associated with the appearance of abnormalities that worsen with the progression of the disease. These patients were compared with a matched group of 12 patients with advanced idiopathic Parkinson's disease. Abnormal background rhythms were found in eight of 12 patients with Parkinson's, whereas all 12 patients with PSP had normal background rhythms on initial examination. Monorhythmic frontal delta was present in a high percentage (42%) of patients with PSP.