VERDICT MRI for Prostate Cancer: Intracellular Volume Fraction versus Apparent Diffusion Coefficient

E Johnston,Elisenda Bonet-Carne,Uran Ferizi,Ben Yvernault,Hayley Pye,Dominic Patel,Joey Clemente,Wivijin Piga,Susan Heavey,Harbir S. Sidhu,Francesco Giganti,James O’Callaghan,Mrishta Brizmohun Appayya,Alistair Grey,Alexandra Saborowska,Sebastien Ourselin,David J. Hawkes,Caroline M. Moore,Mark Emberton,Hashim U. Ahmed,Hayley Whitaker,Manuel Rodriguez-Justo,A. Freeman,David Atkinson,Daniel C. Alexander,Eleftheria Panagiotaki,Shonit Punwani

VERDICT MRI for Prostate Cancer: Intracellular Volume Fraction versus Apparent Diffusion Coefficient

2019

The intracellular volume fraction derived from Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumors (VERDICT) MRI enables better differentiation of a Gleason 4 lesion from benign and/or Gleason grade 3+3 lesions in prostate cancer with a high level of repeatability and similar image quality compared with apparent diffusion coefficient values.

Keywords:

Volume fraction
Pathology
Restricted Diffusion
Medicine
Intracellular
Effective diffusion coefficient
Cytometry
Prostate cancer
Lesion
Extracellular

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