Research and development of biodegradable microneedles

Microneedles are a new type of transdermal drug delivery.It can create a micron-level drug delivery channel on the skin and enhance the permeability of skin for drugs,especially macromolecular drugs,and it does not reach to the nerves in deep skin tissue.Because of using biodegradable materials as a substrate,biodegradable microneedle has the characteristics of biodegradable,self-degradation in the skin,which can solve the difficulty of microneedles broken into skin.As a new transdermal drug delivery technology,it might be an ideal vehicle for biological macromolecules,peptides,vaccines and other drugs.This article provided an overview of the characteristics of biodegradable microneedles,manufacture method,the matrix of choice,application,existing problems and so on.