Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors.

Zachary Armstrong,Chi-Lin Kuo,D. Lahav,Bing Liu,R. Johnson,Thomas J. M. Beenakker,Casper de Boer,C.S. Wong,Erwin R. van Rijssel,M. Debets,Bogdan I. Florea,Colin Hissink,Rolf G. Boot,Paul P. Geurink,Huib Ovaa,Mario van der Stelt,Gijsbert A. van der Marel,Jeroen D. C. Codée,Johannes M. F. G. Aerts,Liang Wu,Herman S. Overkleeft,Gideon J. Davies

Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors.

2020

Golgi mannosidase II (GMII) catalyzes the sequential hydrolysis of two mannosyl residues from GlcNAcMan5GlcNAc2 to produce (GlcNAcMan3GlcNAc2), the precursor for all complex N-glycans, including th...

Keywords:

Biochemistry
Chemistry
Golgi apparatus
Organic chemistry
Mannosidases
Mannosidase II
Activity-based proteomics
Hydrolysis

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