DISSOLUTION RATE ENHANCEMENT OF POORLY SOLUBLE BICALUTAMIDE USING β­ CYCLODEXTRIN INCLUSION COMPLEXATION

The purpose of this study was to improve the dissolution rate of poorly soluble bicalutamide drug with cyclodextrin complexation by following different techniques like spray drying, solvent evaporation and kneading method. Bicalutamide is a non‐steroidal anti androgen. The effect of β‐cyclodextrin on the dissolution rate of bicalutamide was investigated by evaluating inclusion complexes. The present invention relates to the inclusion complexes made by β‐cyclodextrins and the methods for enhancing the bioavailability of bicalutamide. Solid inclusion complexes were prepared by conventional methods like spray drying, solvent evaporation and kneading techniques. Optimized complex was characterized by using p owder x‐ray diffractometry, and FTIR. In vitro s tudies showed that the dissolution rate of bicalutamide was significantly improved by the complexation with β‐cyclodextrin with respect to the drug alone. In contrast, kneading complexes showed highest dissolution rate than the other conventional techniques.