Histogram analysis of 11C-methionine integrated PET/MRI may facilitate to determine the O6-methylguanylmethyltransferase methylation status in gliomas

ObjectiveWe evaluate the O6-methylguanylmethyltransferase (MGMT) methylation status noninvasively by analyzing radiomics features of 11C-methionine (MET) PET images, which may reflect the detailed biological properties of gliomas.Patients and methodsFifty-seven patients with histopathologically conf