Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia

2015 
The human erythrocyte travels nearly 300 miles through 170,000 circuits of the circulatory system during its 120-day lifespan. This prolonged voyage subjects the red cell membrane to high and varied shear forces, to compression and stretching when traversing sinusoidal capillary beds, to osmotic
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