Conjugates comprising an antitumor agent and its use.

The compound (WZM) of the invention comprises an element (M) selected from the group consisting MARKERS AND THERAPEUTIC AGENTS TO HAVE A SITUATION ACTIVE intracellularly (SA, attached to a ligand (WZ, comprising an arm (Z) KINGDOM A terminal group (W), wherein the connection between the arm (Z) of the ligand (WZ) and element (M) prevents the penetration Intracellular COMPOUND (W-Z_M) and / or inhibits expression of the marker (M ) because this connection is selectively separable BY secreted by target cells FACTORS manner that allows expression of the marker (M) or penetration of the therapeutic agent (M) in these cells TARGETS, AND WHY THE TERMINAL GROUP (W) ensures stability COMPOUND (WZM) in serum and BLOOD CIRCULATION.