Mechanism of Qingfeipaidu Decoction on COVID-19 Based on Network Pharmacology/ 基于网络药理学研究清肺排毒汤治疗新型冠状病毒肺炎的作用机制

Objective: To study Qingfeipaidu decoction and its mechanism in the treatment of COVID-19 based on network pharmacology Methods: TCMSP database was used to search and screen the active components of Qingfeipaidu decoction, and GeneGards database was used to predict and screen the disease target, the active component-target network diagram was established STRING was used to construct protein-protein interaction (PPI) network Gene Ontology (Go) and KEGG enrichment analysis were performed, the target signal pathway network map was drawn Results: A total of 217 targets of traditional Chinese medicine and 200 targets of COVID-19 were screened, then 51 common drug-disease targets were obtained, mostly enriched in biological processes and 30 signaling pathways, such as TNF signaling pathway, IL-17 signaling pathway, NF-κB signaling pathway and Th17 cell differentiation Conclusion: The five main active components of Qingfeipaidu decoction in the treatment of COVID-19 are quercetin, luteolin, kaempferol, naringin and isorhamnetine They can inhibit inflammatory reaction, regulate immune function, reduce lung injury and protect nerve function by regulating targets to achieve the purpose of treating COVID-19, such as mapk1, mapk3, mapk8, Mapk14, IL6, RELA and STAT1 and so on