Modelling of ftorafur and 5-fluorouracil pharmacokinetics following oral UFT administration. A population study in 30 patients with advanced breast cancer

S. Urien,P. Fumoleau,Mario Campone,Pierre Kerbrat,J. Bonneterre,P. Fargeot,R. Deporte-Fety

Modelling of ftorafur and 5-fluorouracil pharmacokinetics following oral UFT administration. A population study in 30 patients with advanced breast cancer

2003

S. Urien
P. Fumoleau
Mario Campone
Pierre Kerbrat
J. Bonneterre
P. Fargeot
R. Deporte-Fety

Purpose The pharmacokinetics of ftorafur, 5-fluorouracil (5FU) and uracil were investigated in order to built a population pharmacokinetic model for the anticancer drug UFT, administered with leucovorin and vinorelbine.

Keywords:

Oral administration
Breast cancer
Fluorouracil
Vinorelbine
Pharmacology
Tegafur
Population
Pharmacokinetics
Medicine
Metastatic breast cancer
Antimetabolite
Chemotherapy

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