Detection of circulating immune complexes in patients with hemorrhagic fever with renal syndrome

Severe renal pathology, a long incubation period (up to 3 weeks), a rise in the level of immunoglobulins in the first days from the onset of the disease, slowly developing clinical symptoms (within 2-3 weeks) suggest an important role of immune complexes in the pathogenesis of hemorrhagic fever with renal syndrome ( HFRS) in humans.