The Function of Normal and Familial Hypertrophic Cardiomyopathy-Associated Tropomyosin

This review will focus on the role of sarcomeric tropomyosin during the assembly and function of thin filaments in striated muscle. Particular emphasis will be devoted to how mutations in familial hypertrophic cardiomyopathy influence these processes. Due to the complex and extensive nature of this topic, this review will not address the role of tropomyosin in the cytoskeleton; however, excellent articles on this topic have addressed this area (Lin et al., 1988; Hegmann et al., 1989).