Just-Dip-It (Potentiometric Ion-Selective Electrode): An Innovative Way of Greening Analytical Chemistry

“Green analytical chemistry” (GAC) is a vital area towards the concept of sustainability. As a consequence of the widespread application of HPLC in drug-related analytical investigations and the resulting contamination of the environment with organic solvents questions have been raised about the toxicity/greenness of HPLC in the ecosystem. Traditional analytical separation technologies yield approximately 50 mL of waste per analytical data point. To this end, the pharmaceutical community continues to search for greener opportunities to markedly reduce the amount of organic waste produced and move from conventional offline separation based methodologies to greener in-line alternatives. In this contribution, we’re adopting a “Just-Dip-It” approach with the ultimate goal of advancing and exploiting the potentiometric sensors to their most effective use in different disciplines of drug development. The unique abilities of these ion-selective electrodes (ISEs) for in-line measurements is the key driver for ado...