Safety analysis of endoscopic ultrasound-guided fine needle aspiration of pancreatic lesions

Objective To assess the safety of endoscopic ultrasound-guided fine-needle aspiration （EUS-FNA） of pancreatic lesions. Methods Patients who underwent EUS-FNA of a pancreatic lesion between January 2005 and June 2007were studied retrospectively. Possible risk factors were assessed by using logistic analysis. Results In 119 patients who underwent pancreatic EUS-FNA, mild acute pancreatitis were observed in 1 （0. 84% ） patient after the operation. No complication occurred in 12 patients with regional portal vein hypertension. Nine patients （7.6%） showed hyperamylasemia 3 h after the procedure, rangeing from 197 to 835 U/L, with an average of （327 ＋ 200） U/L. Blood amylase level kept increasing 24 h postoperatively in 6 cases of the 9. Logistic regression analysis showed past history of acute pancreatitis, gender, needle size, number of puncture, cystic foci, preoperative blood amylase level and location of foei would not possibly be the risk factors of hyperamylasemia. Conclusion Incidence of complications after EUS-FNA is 0. 84% , and the occurrence rate of hyperamylasemia is 7.6%, indicating, EUS-FNA is a safe procedure. Key words: Endoscopic uhrasonography ;  Biopsy, needle ;  Pancreas;  Hyperamylasemia