Sleep disruption in medicine students and its relationship with impaired academic performance: A systematic review and meta-analysis.

Summary Sleep disruption severely impairs learning ability, affecting academic performance in students. This systematic review and meta-analysis aimed at assessing the prevalence of sleep disruption in medical students and its relationship with academic performance. PubMed, Web of Sciences, EBSCO and SciELO databases searches allowed to retrieve 41 papers with data about the prevalence of sleep deprivation, 20 of which also contained data on its association with academic performance. Poor sleep quality was reported by 5,646 out of 14,170 students in 29 studies (39.8%, 95% confidence interval= 39.0-40.6%), insufficient sleep duration by 3,762/12,906 students in 28 studies (29.1%, 23.3-29.9%) and excessive diurnal sleepiness by 1,324/3,688 students in 13 studies (35.9%, 34.3-37.4). Academic grades correlated significantly with sleep quality scores (r, 95% CI= 0.15, 0.05 to 0.26, random-effects model; p=0.002, n=10,420 subjects, k=15 studies) and diurnal sleepiness (r=-0.12, -0.19/-0.06 under the fixed effects model, p