Effects of Acute Administration of Acetazolamide and Frusemide on Lithium Clearance in Humans

To investigate the mechanism(s) of acute frusemide-induced increases in FE LI , the effects of frusemide and acetazolamide, the carbonic anhydrase inhibiting agent, were evaluated in 19 healthy subjects either before or after pretreatement with acetazolamide or frusemide, furthermore, it appears that frusemide and acetazolamide affect lithium reabsorption by different and independent mechanism(s), possibly acting at different nephron site(s)