2' Biaryl amides as novel and subtype selective M1 agonists. Part II: Further optimization and profiling

Abstract Further optimization of the biaryl amide series via extensively exploring structure–activity relationships resulted in potent and subtype selective M 1 agonists exemplified by compounds 9a and 9j with good rat PK properties including CNS penetration. Synthesis, structure–activity relationships, subtype selectivity for M 1 over M 2–5 , and DMPK properties of these novel compounds are described.