Reduced-intensity cord blood transplantation following a regimen using fludarabine and busulfan in adult patients with advanced hematologic malignancies.

7036 Background: Cord blood transplantation has grown as an effective alternative therapy for treating patients with advanced or high-risk hematologic malignancies who have no suitable related or unrelated donor. We report the results of reduced-intensity cord blood transplantation (RI-CBT) following a regimen using fludarabine and busulfan in adult patients with advanced hematologic malignancies. Methods: 45 patients (median age, 62 years; range, 26-74 years) underwent RI-CBT at Teikyo University Chiba Medical Center and Tsukuba Memorial Hospital between April 2004 and November 2013. Preparative regimens consisted of fludarabine 30 mg/m2 for 6 days and busulfan 0.8 mg/kg x 4 for 2 or 4days. Tacrolimus was used for prophylaxis of graft-vs-host disease (GVHD). The median infused total cell dose was 2.78 x 107/kg (range, 1.94-5.53 x 107/kg). Results: 24 patients achieved primary neutrophil engraftment after a median of 22 days(range, 14-47). 12 of 24 patients with engraftment achieved complete donor-type ch...