solubility ph and temperature are critical parameters of furosemide in elastomeric pump infusion solving a problem for clinical employment

2019 
Abstract Objective: To determine the furosemide infusion availability considering several critical physical parameters. Methods: The filling protocol has been carried out in U.Ma.Ca., Hospital Pharmacy Unit of Bari (Italy), for furosemide in elastomeric pump. The qualitative and qualitative aspect have been monitored with HPLC. Results: This innovative protocol permits to have a stable infusing concentration of furosemide without precipitation. Conclusion: Both the filling developed method and the protocol to monitor qualitative and quantitative furosemide infusing concentration with elastomeric pump are suggested as guidelines for clinical employment. Keywords Elastomeric pump; Furosemide; HPLC; pH; Solubility
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