Abstract P4-05-17: Mammaglobin is a potent regulator of breast cancer processes leading to disease progression

Metastasis is the major cause of death in women suffering from breast cancer. To provide a better understand breast cancer progression, we have studied the role of mammaglobine-1 (MGB1) gene in breast cancer pathogenesis. MGB1 has been extensively studied as a diagnostic biomarker due to its abundant expression in mammary cancer cells. Yet, MGB19s role in disease progression is still unknown. Our experimental results demonstrate for the first time that MGB1 in a pivotal regulator on breast cancer malignancy. More precisely, loss of MGB1 expression correlates with a decrease in proliferation, spheroid formation, migration, and invasion capacities of breast cancer cells. Concomitantly, we also observe that MGB1 expression activates pro-malignant signaling cascades such as MAPKs, focal adhesion kinase (FAK) and NFkB pathways. Moreover, MGB1 promote epithelial to mesenchymal (EMT) features which coincide with our findings. Our study provides the first evidence for MGB1 as regulator of breast cancer malignancy and disease progression. Citation Format: Roxann Guerrette, Nadia Picot, Gilles Robichaud. Mammaglobin is a potent regulator of breast cancer processes leading to disease progression [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-05-17.