P MASON, J ADAMS, D V MORRIS, M TUCKER, J PRICE, Z VOULGARIS, Z M VAN DER SPUY, I SUTHERLAND, G R CHAMBERS, S WHITE, M J WHEELER, H S JACOBS

Ovulation was successfully induced with luteinising hormone releasing hormone in 28 women with hypo thalamic amenorrhoea who had failed to respond to treatment with clomiphene. Luteinising hormone re? leasing hormone was administered in a pulsatile manner with miniaturised automatic infusion systems. The rate of ovarian follicular maturation, as monitored by serial pelvic ultrasonography, was similar to that observed in spontaneous cycles. Endocrine assessment by serial measurement of gonadotrophin, oestradiol, and pro? gesterone concentrations showed hormone concentra? tions to be within the normal range. Intravenous treat? ment was required in only two patients, the remainder responding satisfactorily to subcutaneous infusion. All patients conceived within six cycles of treatment, and only one multiple pregnancy occurred.