Mediators of immune responses in cerebrospinal fluid with viral infections of central nervous system

The revue includes contemporary information about the immune factors in cerebrospinal fluid (CSF) of patients with viral infections of central nervous system (CNS). The CSF concentrations of immunoglobulins, complement components, virus-specific antibodies, and inflammation mediators reflect their pathogenetic role in infection, that allows to use these parameters for dyagnostic improvement, course of disease prognosis, and in therapy monitoring. Detection in CSF of cytokines and chemokines, that are reflecting peculiarities of system and local immune responses in infection course, is especially clinically significant.