Combining ADCs with Immuno-Oncology Agents

Immuno-oncology (IO) has emerged as one of the most promising approaches to improve the therapeutic efficacy and durability of clinical responses in cancer patients. However, despite the clinical breakthroughs achieved with immuno-therapies, such as checkpoint blockade, the overall proportion of patients experiencing durable responses to single agent immuno-therapy remains relatively small. Therefore, the real promise for most cancer patients does not lie in monotherapeutic approaches but in synergistic combination therapies, which combine the best of IO with the immune-promoting/supporting properties of other therapeutic modalities. The latter help to breach physical barriers, to overcome immunosuppressive networks within the tumor microenvironment and improve immune cell infiltration into tumors.