Common Promoter C516T Polymorphism in the ApoB Gene Is an Independent Predictor of Carotid Atherosclerotic Disease in Subjects Presenting a Broad Range of Plasma Cholesterol Levels
2004
Objective— A common polymorphism in the promoter of the apolipoprotein B (apoB) gene, a C to T change at position −516, increases the transcription rate of apoB, resulting in elevated circulating levels of low-density lipoprotein (LDL) cholesterol. Methods and Results— We tested the hypothesis that carriers of the −516T allele, who may display consistent elevation in plasma cholesterol over their lifetime, may present more extensive atherosclerotic disease than noncarriers. Genotyping of the apoB 516 C/T promoter polymorphism was performed in 326 subjects at low cardiovascular risk. Homozygotes for allele T displayed higher plasma levels of apoB and LDL than did heterozygotes. Furthermore, both homozygotes and heterozygotes for allele T exhibited higher plasma levels of apoB and LDL than did homozygotes for allele C ( P P Conclusions— Our data indicate that a C to T change at position −516 of the apoB gene is independently associated with the presence of carotid atherosclerotic disease. Identification of the −516C/T polymorphism may therefore contribute to the estimation of overall cardiovascular risk.
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