Efficacy and Safety of Long-term RN-1 Treatment to Increase HbF in Baboons

To the editor: Elevated levels of fetal hemoglobin (HbF; α2γ2) lessen the severity of symptoms and increase the life span of patients with sickle cell disease (SCD).[1][1],[2][2] Hydroxyurea, the only approved drug for the treatment of SCD, is ineffective in a large proportion of patients, and