FEASIBILITY OF A NEW DUAL-PASTE PRESENTATION OF INJECTABLE BRUSHITE CEMENTS

This work focuses on injectable calcium phosphate cements (CPC) which, in contrast to conventional hydroxyapatite cements, are converted into brushite (dicalcium phosphate dihydrate, DCPD) as a result of their consolidation processes. The so–called brushite cements are prepared by adding water to mixtures of β-tricalcium phosphate (β-TCP) and monocalcium phosphate monohydrate (MCPM) powders, in such proportions as to obtain flowable pastes. Setting and consolidation occur as a result of dissolution-precipitation reactions inducing the formation of new brushite crystals in de cement paste. As DCPD has higher solubility than hydroxyapatite (HAP) in physiological conditions, brushite cements are expected to show superior biodegradability and faster resorption in clinical applications. Previous in vivo investigations have shown that brushite cements are promising synthetic materials for the reconstruction of bone defects ,. Compared to other biocompatible polymeric cements used so far, this inorganic material meets numerous interesting specifications such as : injectability, workability, low heat release upon setting, in situ consolidation, biodegrability, resorbability and osteoconductibility, thus enabling bone regeneration. The step of developement presented here is related to a brushite cement formulation dedicated to the treatment of parodontic lesions in the dental field. This work aims at achieving a new galenic