Применение импульсной осциллометрии у больных муковисцидозом

Impulse oscillometry (IOS) measures the total respiratory system impedance (Z) at incremental frequencies during normal tidal breathing. Our aim was to establish the total respiratory impedance and how IOS measurements relate to conventional lung function indices in patients with cystic fibrosis (CF). Results from spirometry, static lung volumes and IOS (R, X, Z, resonant frequency (FR) and reactance area 5Hz — FR (AX)) were compared in 66 adult CF patients recruited from CF Care Centre of Moscow. Patients had airway obstruction (FEV 1 = 57 % pred. ), hyperinflation (RV = 253 % pred., FRC = 158 % pred. , RV / TLC = 52 %). IOS demonstrated a frequency dependent increase in R (R5 = 173 % pred. , R20 = 140 % pred. ) and a decrease in X (X5 = –0,23 kPa/L / s) with a shift in FR to higher frequencies (FR = 18 Hz, AX = 1,4 kPa / L). There were significant correlations between FR, X20, R5, R20, AX and conventional lung function indices (FEV 1 = – 0,74; 0,78; –0,42; –0,31 and –0,76 respectively). The data indicate that measurement of reactance and FR may reflect the degree of airway obstruction. IOS is an effort independent measurement that could be used in clinical routine especially in patients with severe lung diseases.