One kind of pantoprazole sodium and freeze-dried injection preparation

Applied to one kind of freeze-dried powder of pantoprazole sodium pantoprazole sodium rabeprazole art industrial production formulation comprising pantoprazole sodium, lyoprotectant, and pH adjusting agent, said lyoprotectant trehalose; the selected anhydrous pantoprazole sodium pantoprazole sodium, pantoprazole sodium hydrates of one or more; the pantoprazole sodium monohydrate pantoprazole selected Torr monohydrate sodium omeprazole, pantoprazole, one or more of the azole sodium dihydrate; preparation method of pantoprazole sodium in the lyophilized powder, said process comprising the steps of: said The formulation and amount of pantoprazole sodium lyoprotectant, an appropriate amount of added water for injection to dissolve, then activated charcoal was added, stirred, filtered decarburization; supplemented with appropriate amount of water for injection, stirring evenly, with a pH adjusted to a pH adjusting agent 9 to 12, which supplemented with water for injection to a prescribed amount; sterile filtered drug solution, filled in a vial; after lyophilization tamponade. The invention is reasonable prescription, high stability, good color and appearance of the molded, simple preparation method.