Prohibitin as a novel molecular target for the therapy of tumor and metabolic diseases

Prohibitin(PHB) is a highly conserved and ubiquitously distributed protein involving in the key biological processes of cell cycle regulation,cell signaling mediation,aging,apoptosis,proliferation,tumor suppression and maintenance of mitochondrial structure and function and so on.The diverse array of functions and different locations of PHB,together with the phenomenon of the differential expression in a myriad of diseases,suggest that PHB is involved in the initiation and development of diseases.Thus,PHB would be a useful drug target for the treatment of variety of diseases such as tumor,diabetes and obesity.