Effect of DS-2969b, a novel GyrB inhibitor, on rat and monkey intestinal microbiota

Abstract DS-2969b, a novel GyrB inhibitor, transiently and reversibly altered the counts of limited intestinal microbiota at around 10 μg/g of faecal levels in rats and monkeys. Considering the high activity of DS-2969b against Clostridium difficile , 10 μg/g of faecal levels would be sufficient for clearing C. difficile from the intestine.